Expert Opinion

"At the moment, those undergoing the treatment are between 16 and 53. On average, after only 10 sessions, not only is there great improvement in vision but it is also maintained for at least two years."
Prof Donald Tan, Director Singapore Eye Research Institute and Deputy Director, Singapore National Eye Centre
"This treatment helps the brain to better understand the images the eyes are sending it, rather than altering the images the eyes receive by using corrective lenses or surgically altering the eye itself."
Dr Chan Wing Kwong, Senior Consultant and Head of Refractive Surgery Centre, Singapore National Eye Centre
"For example, select an item in your house that you cannot see clearly. After that, every five sessions, take a look at the object again and you will notice that your vision has become sharper. These are testimonials from patients who have experienced this."
Prof Donald Tan, Director Singapore Eye Research Institute and Deputy Director, Singapore National Eye Centre
"Vision is dependent on two things, how your eye receives the image and how your brain interprets the image. NeuroVision helps the brain to interpret sharper images."
Dr Chan Wing Kwong, Senior Consultant and Head of Refractive Surgery Centre, Singapore National Eye Centre
"Naturally we were quite skeptical about the whole thing, because traditionally, ophthalmologists thought that apart from glasses and surgery, other methods wouldn't work for myopia. But we tried it out, and it did work."
Dr Chan Wing Kwong, Senior Consultant and Head of Refractive Surgery Centre, Singapore National Eye Centre
Clinical Results

Thousands of clinical trial participants and patients have reported significant improvement in their vision by two rows on the visual acuity eye chart, and 100% increase in contrast sensitivity function, on average.

 

Studies Related to NeuroVision™ Amblyopia Treatment

graph_acuitythreshold
Figure 1: Change in Visual Acuity during NeuroVision™ of three amblyopic patients and one control patient
graph_acuitylog
Figure 2: Change in visual acuity during NeuroVision treatment of two treatment groups and one control group

Polat et al. studied 54 adult amblyopic patients who were randomized to amblyopia NVT treatment or a placebo vision-training program. Pre treatment visual acuity in both study groups were 0.42 logMAR, and this improved by 2.5 lines to 20/30 in the NVT treatment group, with no improvement in the control group. The Contrast Sensitivity Function (CSF) improved to within the normal range. These improvements in acuity and CSF were sustained after 12 months1.

 

Studies Related to NeuroVision™ Low Myopia and Post-LASIK Training Programs

UACSF
Figure 3: UACSF improvement in study group subjects maintained after 12 months (n-20 eyes)
UAVA improvement

Figure 4: UAVA improvement in study group subjects maintained after 12 months (n-20 eyes)

Tan et al. reported mean improvement of 2.8 logMar lines in distance unaided visual acuity (UAVA) for 55 low myopes after completion of the NVT training. The improvements were shown to be retained for at least 12 months5.

At 2007 Asia-ARVO, Tan et al. reported mean distance UAVA improvement was 2.4 ETDRS lines(from 0.32 to 0.08 logMar) in distance unaided (UAVA) for 22 post-refractive surgery patients after completion of the NVT training. Mean distance unaided CSF improved at all spatial frequencies to within the normal range6. Similar result reported by Durrie et al in 2007 on the efficacy of NV on low myopes.


  Group A Group B
Baseline unaided VA (logMar)
Mean (SD)
Median (range)
0.43 (0.15)
0.40 (0.20 - 0.80)
0.34 (0.10)
0.32 (0.20 - 0.62)
End of treatment VA (logMar)
Mean (SD)
Median (range)
0.25 (0.17)
0.24 (-0.30 - 0.66)
0.31 (0.17)
0.28 (-0.12 - 0.70)
Improvement of VA (logMar)
Mean (SD)
Median (range)
0.183 (0.155)
0.18 (-0.28 - 0.60)
0.03 (0.144)
0.04 (-0.30 - 0.34)

Table 1: Summary of baseline VA, end of treatment VA and improvement of VA

  Group A Group B Statistical Significance (p) Odds Ratio 95% confidence Interval
Average Improvement in UAVA 0.183 logMar 0.030 logMar      
% of subjects who improved 2 Lines or above in Both Eyes 31.3% 5.9% p=0.034
Fisher's Extract
Test
7.304 0.908 to 58.771
% of subjects who improved 2 Lines or above in at least One Eye 64.2% 11.8% p<0.0005
Chi-square Test
13.438 2.830 to 63.796

Table 2: Summary of Statistical Analysis

Tan et al. conducted a randomized controlled trial evaluating the efficacy of NVT in low myopia. The interim results presented by Tan et al, at Asia ARVO 2008 confirmed that statistically significant difference in unaided visual acuity between the masked treatment groups and suggested on completion of the NVT was likely to provide the definitive evidence of efficacy and safety of NVT treatment in improving visual acuity and contrast sensitivity function in adult low myopes10.



PL Visual AcuityFigure 5: Change in unaided visual acuity during NeuroVision treatment
Spatial Frequency PLFigure 6: Change in unaided contrast sensitivity during the NeuroVision treatment.

Lim et al. reported a single case of NVT for the treatment low myopic regression five years after myopic LASIK. The patient improved 2.8 lines in the right eye and 1.6 lines in the left eye following NVT2.

Unaided VAFigure 7: Unaided VA is retained for 24 months after the end of the NeuroVision treatment
Unaided CSFFigure 8: Unaided contrast sensitivity is retained for 24 months after the end of the NeuroVision treatment

Siow et al. reported 2 years follow-up results of visual acuity and contrast sensitivity enhancement in commercial patients with low myopia using NVT training program. Mean logMAR UAVA improved from 0.404 to 0.110 at the end of treatment approximately 3 rows of improvement in acuity. 74% of this improvement was maintained after 24 months.

Mean baseline UCSF at 1.5, 3, 6, 12, 18 cpd was: 39, 41, 23, 7, 2 improving to: 117, 145, 148, 61, 18. 76% of this improvement was maintained for 24 months. The sesults suggest that NVC treatment improves UAVA and UCSF in low myopes. This improvement is retained for at least 24 months after treatment9.


Studies Related to NeuroVision™ Sports Vision Training Program

n=20 Treatment Group
Mean PHVA, PLVA, MHVA before treatment 0.06, 0.21, 0.19
(±0.02, ±0.02, ±0.02)
Mean PHVA, PLVA, MHVA after treatment -0.05, 0.14, 0.08
(±0.02, ±0.02, ±0.02)
PHVA, PLVA, MHVA improvement post treatment 0.11, 0.07, 0.11
(±0.03, ±0.02, ±0.02)
Mean PHVA, PLVA, MHVA 3 mth after treatment -0.05, 0.19, 0.09
(±0.03, ±0.05, ±0.04)
Mean cycloplegic spherical equivalence refraction before treatment -2.70D
(±0.49)
Mean cycloplegic spherical equivalence refraction after treatment -2.16D
(±0.58)
Percentage with better than 0.00 logMAR VA (6/6) post treatment 70%

Table 3: Summary of visual functions of subjects had undergone NeuroVision treatment
Neurovision CSFFigure 9: Summary of contrast sensitivity functions of subjects had undergone NeuroVision treatment

Ng et al. reported mean habitual VA improved from 0.06 (0 to 0.28) to -0.05 (-0.22 to 0) logMAR units in a group of 11 young adults at 2007 Asia-ARVO. 70% of the eyes achieved VA better than 6/6 at the end of NeuroVision treatment. Statistical significant improvements were found in contrast sensitivity after the end of treatment. The results demonstrate super vision is achieved after the Neurovision treatment7.


Studies Related to "NeuroLASIK" Treatment

n=98 Treatment Group Control Group
All patients after "NeuroLASIK"
Unaided Visual Acuity improvement
Contrast Sensitivity improvement
0.8 Snellen Lines
79%
0.28 Snellen Lines
52%
Patients with vision worse than 20/20
after "NeuroLASIK"

Unaided Visual Acuity improvement
Contrast Sensitivity improvement

1.56 Snellen Lines
90%

0.34 Snellen Lines
47%

Table 3: Comparison of Unaided VA and Contrast Sensitivity improvement between "NeuroLASIK" treatment group and control group

Durrie et al. conducted a prospective, randomized, multicenter placebo controlled study comparing visual cortex training after LASIK ("NeuroLASIK") to sham treatment (video game) following LASIK in 98 eyes. Researchers found 0.8 Snellen lines of UAVA and 79% improvement in contrast sensitivity in the treatment group relative to a 0.28 line improvement and 52% improvement in CSF in the control group. Patients who were worse than 20/20 after LASIK improved 1.56 Snellen lines of UAVA and 90% improvement in CSF with NVT relative to the 0.34 lines and 47% CSF improvement in the control group. The results suggested that patients who had worse vision improved more and that perhaps there is a cortical limit to how much a patient can improve11.

References

  1. Improving vision in adult amblyopia by perceptual learning
    PNAS 2004
  2. NeuroVision Treatment for Low Myopia Following LASIK Regression
    Journal of Refractive Surgery 2006
  3. Donald Tan, MD, on NeuroVision™, a Non-optical Approach to Correcting the Effects of Refractive Error
    Refractive Eyecare 2006
  4. Efficacy of neural vision therapy to enhance contrast sensitivity function and visual acuity in low myopia
    J Cataract Refract Surg 2008
  5. Improving CSF in Subjects with Low Degrees of Myopia using Neural Vision CorrectionÔ (NVCÔ) Technology
    Donald Tan poster presented in 2005 ARVO
  6. The Alternative Approach to Visual Blur: NeuroVision Treatment (NVCÔ) for Myopia, Post-Refractive Surgery and Presbyopia
    Donald Tan, Chua Wei Han, Allan Fong poster presented in 2007 Asia AVRO
  7. Cortical enhancement of Habitual VA of subjects using Neural Vision Correction Technology
    Chris NG, Wilfred TANG, Donald TAN, Nir ELLENBOGAN poster presented in 2007 Asia AVRO
  8. Efficacy of NeuroVision Technology (NVC) in Enhancing Unaided Vision in Early Presbyopes and Low Myopes
    Erin D. Stahl, MD, Daniel S. Durrie, MD poster presented in 2007 AAO
  9. 2 Years Follow-Up Results of Visual Acuity and Contrast Sensitivity Enhancement in Patients with Low Myopia using NeuroVision's Neural Vision Correction (NVC) Technology
    Ka-Lin Siow, Donald T.H. Tan poster presented in IMC 2008
  10. A Randomised Controlled Trial Evaluating the Efficacy of Neurovision's Neural Vision Correction Technology in Enhancing Unaided Visual Acuity in Adults with Low Myopia
    Muhammad Nazarul, Allan Fong, Donald Tan presented in 2008 ARVO
  11. Computer-Based Primary Visual Cortex Training Combined with LASIK for Treatment of Low Myopia
    Erin D. Stahl, MD, Daniel S. Durrie, MD presented in 2009 ASCRS